The tumor microenvironment (TME) is composed of tumor cells, endothelial cells, tumor stromal cells (including stromal fibroblasts), immune cells (such as lymphocytes, macrophages, and microglia), and non-cellular ECM constituents (such as collagen, fibronectin, hyaluronan, and laminin) [100,101]. The gene discussed is FN1; the disease is neoplasm.