The target landscape of hsa-miR-4472 converges on calcium signaling and synaptic release (HCN2, STIM1, SYT5, UNC13A, SCAMP2/5, SLC8A2) and on Wnt/axon-guidance modules (DVL3, RSPO4, PTK7, SEMA6A, EFNA3, PLXNA3) [22,54,55], providing a mechanistic link to asthenia via reduced neuronal excitability and less efficient signal transmission. Here, HCN2 is linked to asthenia.