The investigation of the updated dataset of CRP PPIs identified significant enrichment of numerous pathways, including those involved in biosynthesis of glycosaminoglycans, extracellular matrix (ECM)–receptor interactions, the regulation of focal adhesions, advanced glycosylated end-product receptor signaling (AGE-RAGE), and various mitogenic and cancer-associated pathways (e.g., TGFβ, PI3K-Akt) (Figure 2). This evidence concerns the gene TGFB1 and cancer.