CRP and neoplasm: Although reviewed extensively elsewhere [12,84,93], the ability of CRP to regulate (1) fibroblast motility and differentiation, (2) immune cell recruitment, adhesion, and invasion, and (3) endothelial angiogenic behavior all relate to the many pathways that are exploited by tumor cells to maintain the plasticity required to engage in EMT or MET, as needed, to grow and metastasize successfully.