The novel interactions and potential new activities of CRP on glycoprotein biosynthesis and thus ECM composition, ECM-dependent cell–cell signaling, as well as TGFβ1 and MAPK signaling, altogether support the hypothesis that the role of CRP in the microenvironmental control of tumor cell EMT/MET is likely immensely underappreciated currently, despite growing evidence indicating its importance in the TME [6]. Here, TGFB1 is linked to neoplasm.