TGFB1 and cancer: As alluded to above, the CRP PPIs enriched in the “Hallmarks of Cancer: Epithelial-to-Mesenchymal Transition” (Table 3 and Supplementary Table S3) largely relate to glycoproteins (COL4A2, FN1, LAMA1, LAMC), signaling molecules (TGFB1), or enzymes (QSOX1, TIMP3) directly related to ECM structure and remodeling that may regulate processes underlying cellular plasticity and/or be a result of phenotypic changes.