To examine ADGRG6’s functional role in PAAD cellular proliferation, migration, and invasion processes, we conducted targeted silencing of ADGRG6 mRNA in AsPC-1 and BxPC-3 pancreatic cancer cell lines through specific siRNAs (si-ADGRG6), utilizing si-NC as negative control. The gene discussed is ADGRG6; the disease is pancreatic neoplasm.