Together, these findings indicate that ADGRG6 promotes PAAD progression by activating the NF-κB→STAT6→GATA3 signaling cascade, enhancing the production of inflammatory cytokines such as IL-6 and IL-8, and potentially contributing to tumor–immune crosstalk within the pancreatic tumor microenvironment. This evidence concerns the gene IL6 and pancreatic adenocarcinoma.