ADGRG6 and pancreatic adenocarcinoma: Consistent with this premise, our results demonstrated that ADGRG6 was markedly upregulated in PAAD tissues and cell lines, correlated with aggressive clinicopathological features and poor prognosis, and functionally promoted tumor proliferation, migration, and cytokine secretion across 2D cultures, 3D spheroids, zebrafish xenografts, and murine models.