Given that endothelial-to-mesenchymal transition (EndMT) [40,41,42,43] and macrophage/Treg-driven immunosuppression [44,45] are central to PAAD progression; the findings raise the possibility that ADGRG6 contributes to establishing an immunosuppressive niche. This evidence concerns the gene ADGRG6 and pancreatic adenocarcinoma.