For example, MMP9 and S100A8/A9 are strongly associated with microglial activation and synaptic remodeling [47,48], CCL2 mediates immune-cell recruitment and neuroinflammation in HD and AD models [49], and LCN2 serves as an astrocytic marker of oxidative stress and neuronal injury [50]. The gene discussed is CCL2; the disease is Alzheimer disease.