Besides, heart failure (P < 0.001), chronic airway disease (P = 0.018) and pulmonary heart disease (P < 0.001) were more prominent in females while liver disease (P = 0.079) was more frequent in males.<h4>Conclusions</h4>This study suggests a much higher proportion of HAPC in native Tibetans, and the Hb in HAPC patients remains significant gender-specific and altitude-dependent variations. This evidence concerns the gene GSTM1 and liver disorder.