Analyses were adjusted for vascular risk factors and statin status.<h4>Results</h4>In SAHLSIS, S100A12 was independently associated with recurrent MACE (adjusted hazard ratio (HR), 1.27 [95% confidence interval 1.10-1.45] per doubling of protein level) and stroke (adjusted HR 1.21 [1.01-1.45]). The gene discussed is S100A12; the disease is stroke disorder.