Nevertheless, the relationship between <i>IRF5</i> variants and SLE risk within the Han Chinese demographic remains inadequately characterized.<h4>Materials and methods</h4>Genotyping of two functional single nucleotide variants (SNVs) in <i>IRF5</i> was conducted in 167 individuals with SLE and 246 healthy controls utilizing sequence-specific primer polymerase chain reaction (PCR-SSP). This evidence concerns the gene IRF5 and systemic lupus erythematosus.