JAK1 and neoplasm: Furthermore, it enhanced the infiltration of CD8<sup>+</sup> T cells into the tumor microenvironment and synergistically augmented the efficacy of anti-PD-1 therapy.<h4>Conclusion</h4>Thimerosal exerts dual antitumor roles by direct JAK1/STAT3 inhibition and immune modulation via CD8<sup>+</sup> T cell recruitment.