Anti-spike IgG, IgA, and sIgA levels were quantified using a validated in-house ELISA.<h4>Results</h4>Salivary anti-spike IgG levels were significantly elevated in both stage I/II (<i>p</i> = 0.0002) and stage III/IV (<i>p</i> < 0.0001) periodontitis groups compared to controls, while IgA and sIgA levels did not differ between groups. This evidence concerns the gene CD79A and periodontitis.