CD79A and periodontitis: Analysis of immunoglobulin isotype coordination revealed a strong positive correlation between IgG and IgA in controls (r=0.42, <i>p</i> < 0.0001) and stage I/II periodontitis (r=0.71, <i>p</i> < 0.0001), which was absent in stage III/IV periodontitis (r=0.25, <i>p</i> = 0.06).<h4>Conclusions</h4>Periodontitis was associated with higher salivary anti-spike IgG binding levels, which also showed a strong positive correlation with periodontal bleeding.