Then detect the expression levels of RAGE, HMGB1, and NF-κB in the striatal sample using immunohistochemistry, western blotting, and RT-qPCR.<h4>Results</h4>(1) In PD rats, treatment with FPS-ZM1 improved learning and memory ability and alleviated sensorimotor deficits. The gene discussed is HMGB1; the disease is Parkinson disease.