Surprisingly, her pituitary function evaluation showed only mild central hypothyroidism [(FT4 11.4 pmol/l (normal range 12–22) and TSH 1.9 mU/l (normal range 0.27–4.2)] and hypogonadotropic hypogonadism (E2 47 pmol/l, LH 1.9 u/l, FSH 5.9 u/l). This evidence concerns the gene BRD2 and Central hypothyroidism.