Multivariable Cox regression analysis identified preoperative hepatic congestion [hazard ratio (HR) = 3.042], Wolff-Parkinson-White (WPW) syndrome (HR = 3.463), and elevated alanine aminotransferase (ALT) level (HR = 1.023) as independent risk factors for surgery. The gene discussed is GPT; the disease is Wolff-Parkinson-White syndrome.