Two novel loci in linkage disequilibrium (r<sup>2</sup> = 1) within LTBP1 were associated with higher CRC-specific mortality risk: rs34071846 and rs12712337 (per allele HR: 2.74, CI: 1.91-3.92, p = 3.78 × 10<sup>-8</sup>). This evidence concerns the gene LTBP1 and colorectal carcinoma.