IFIH1 and melanoma: Finally, ADAR1i-124, like siAdar1, upregulated expression of IFN-stimulated genes (ISGs) such as Ifih1 (MDA5), Cxcl9, and Cxcl10 in Yumm1.7 melanoma and HGS2 ovarian cancer (OC) cells (Figures 3B, S4A, and S5A), indicating that ADAR1i-124 activates IFN signaling, a crucial step for effective ICB.18