ADAR and cancer: Rescue experiments using short interfering RNA (siRNAs) targeting downstream components of the ADAR1 pathway (Figure 4C) confirmed that ADAR1i-124-mediated cancer cell eradication depends solely on MDA5 and ZBP1 pathways but is independent of PKR activation in Yumm1.7 mouse melanoma cells used in this experiment (Figures 4E, S4A, S5A, S5F, S5G, S9B, and S9C).