Mutations or amplifications in the PIK3CA gene, mutations in the phosphoinositide-3-kinase regulatory subunit (PIK3R) gene, loss of phosphatase and tensin homolog (PTEN), and mutations or amplifications in AKT isoforms result in uncontrolled activation of this signaling pathway and result in the development of ovarian cancer (56). Here, PIK3CA is linked to ovarian carcinoma.