The VEGF pathway down-regulates VEGF expression, reduces angiogenesis, and tumor growth via the EGCG, Transforming growth factor beta 1 (TGF-β1)/mothers against decapentaplegic (SMAD), and 67-kDa laminin receptor-mediated cAMP response element-binding protein (CREB) pathways. This evidence concerns the gene VEGFA and neoplasm.