NFKB1 and polycystic ovary syndrome: EGCG has been shown to significantly reduce pro-inflammatory cytokines such as TNF-α, IL-1β and IL-6 in PCOS models, in a dose-dependent manner, suggesting that higher doses may yield greater anti-inflammatory effects In PCOS mouse models, catechins were found out to down-regulate the expression of p-NF-κB p65 and other pro-inflammatory parameters, suggesting a potential mechanism by which catechins reduce uterine inflammation (27).