Additionally, it reduces the mRNA levels of proinflammatory cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6), and interleukin-12 (IL-12), both in muscle tissue in vivo and in adipose tissue cells in vitro, thereby alleviating high-fat diet-induced obesity and insulin resistance (37, 38), consistent with the results of facilitating the reduction of skeletal muscle lipid deposition and enhancing adipose tissue lipolysis (39) (Figure 3C). The gene discussed is IL6; the disease is obesity disorder.