IL17A and Alzheimer disease: Although CMC is uncommon in AD APECED, a few reported patients with heterozygous AIRE variants that affect the SAND or PHD1 domains have developed fungal infection/mycosis in the absence of detectable anti-IL-17 autoAbs (∼10–15% vs. >90% in AR APECED) (10, 16, 17, 18, 19, 20).