With a VIF value >2 as a threshold, Leukocyte (VIF = 2.226) was eliminated, and the variables (hypertension, hospitalization due to AECOPD in the prior year, monocyte count, albumin, CRP, In-SII, GOLD categories, intravenous corticotherapy during hospitalization, antibiotics during hospitalization, diuretics, oxygen therapy) remained. This evidence concerns the gene CRP and Hypertension.