Differing from a significant correlation between high EVI1 expression and KMT2A rearrangement established in both adult and pediatric AML patients (9, 10, 13, 17, 36), our observations in adult Ph-negative B-ALL patients indicate an association between KMT2A rearrangement and uniformly fairly low EVI1 expression levels (median, 0.090%, range: 0.0040–0.50%). This evidence concerns the gene RUNX1 and acute lymphoblastic leukemia.