They showed that the apoptosis rates were significantly elevated after knockdown of EVI1 expression in ALL cell lines NALM-16 and REH, and found that EVI1 modulates expression of several apoptosis-related genes (such as BCL2, BCL-x, XIAP, NOXA, PUMA, TRAIL-R1) (17). This evidence concerns the gene BBC3 and acute lymphoblastic leukemia.