In human malignancies, EVI1 is frequently activated by chromosomal rearrangements at the 3q26.2 locus in acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and chronic myeloid leukemia (CML) (3, 4). Here, RUNX1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.