NFASC and Alzheimer disease: The second form of AD NF-κB2 disorders is caused by heterozygosity for truncating variants within the RHD domain (p.A35Efs*10, p.R52*, p.W270*, p.Y294Ifs*4, and p.K321Sfs*160)—the domain responsible for p52 dimerization and DNA binding—resulting in p52/p100 haploinsufficiency (Fig. 1 B).