TBK1 and viral infectious disease: These findings raise the possibility that homozygosity for the R308* TBK1 mutant might underlie a more severe impairment of cell-intrinsic antiviral I-IFN immunity mediated by various pathways than observed for the previously reported TBK1 mutants (whether present in the heterozygous or homozygous state), potentially accounting for the more severe course of the recurrent viral infections in this patient.