IFNG and Mendelian susceptibility to mycobacterial diseases: Lastly, we do not recommend IFNγ as prophylaxis for MSMD; however, IFNγ therapy can be a useful adjunct to anti-mycobacterial antibiotics to treat disseminated NTM in certain IEI such as NEMO, IκBα deficiency, IL12RB1 deficiency, and autosomal dominant IFNγR1 deficiency.