We noted also that the CVID subjects with lower numbers of SM B cells had significantly fewer numbers of IgA+ SM B cells, as compared to those subjects with the infection only phenotype (mean 2.1% ± 2.8 for 46 Group 2 subjects vs. 3.6% ± 3.9% of B cells for 43 Group 1 subjects; P = 0.03) (data not shown). The gene discussed is CD79A; the disease is common variable immunodeficiency.