GALC and Parkinson disease: Of the remaining previously identified GWAS loci regions, several showed differences in effect magnitude between sexes, with the <i>GALC, RERE, ARL6IP6,</i> and <i>RBM8A</i> loci demonstrating statistically significant sex-specific effects.<h4>Conclusions</h4>Overall, PD genetic architecture appears broadly similar between females and males, but the identification of five novel loci and significant differences at select regions highlights the value of sex-stratified analyses for uncovering additional genetic contributors to PD risk beyond those detected in combined analyses.