Serum levels of six key tumor markers—Squamous Cell Carcinoma Antigen (SCCA), Carcinoembryonic Antigen (CEA), Cancer Antigen 125 (CA-125), Cytokeratin 19 Fragment (CYFRA21-1), Neuron-Specific Enolase (NSE), and Pro-Gastrin-Releasing Peptide (ProGRP)—were quantified, and a custom deep neural network, LungPanelNet, was constructed for the classification task. Here, ENO2 is linked to neoplasm.