CYBB and diabetes mellitus: Several factors specific to the Congolese population may modulate NOX2 activity and its pathophysiological impact, making our findings particularly relevant for understanding diabetes in African contexts: The urban population of Brazzaville is undergoing rapid dietary transition characterized by increased consumption of ultra-processed foods rich in trans fatty acids and refined sugars, decreased traditional diet rich in fiber (cassava, plantain, leafy vegetables), and higher dietary AGE (advanced glycation end-product) load from fried and grilled foods.