CYBB and type 2 diabetes mellitus: In this context, the present study aims to evaluate the associations between NOX2 activity and the main inflammatory (IL-6, CRP, COX-2) and apoptotic (Caspase-3) biomarkers in Congolese patients with T2D; explore the influence of family history on NOX2 levels; and analyze the impact of antidiabetic treatments on the oxidative profile, in order to better understand the pathophysiological mechanisms involved and consider potential local therapeutic targets.