Our multivariate analysis identified four independent predictors of NOX2 levels: HbA1c (β = 0.31, p < 0.001), BMI (β = 0.24, p = 0.003), diabetes duration (β = 0.19, p = 0.012), and family history (β = 0.16, p = 0.028). The gene discussed is CYBB; the disease is diabetes mellitus.