Finally, antitumor effects of SLC1A5 inhibitor V9302 in the presence or absence of CD276 were evaluated in NOD/SCID mice (<i>n</i> = 5 per group) bearing KYSE150 xenografts.<h4>Results</h4>CD276 and SLC1A5 upregulated in ESCC tissues (<i>P</i> < 0.05). This evidence concerns the gene CD276 and esophageal squamous cell carcinoma.