PPARG and cancer: The EA treatment enhanced the nuclear localization index of RXRβ in the iWAT by 0.51 (10 mg/kg, 1.9-fold, p < 0.05) and 0.46 (20 mg/kg, 1.7-fold, p < 0.05) compared to cachectic mice.<h4>Conclusions</h4>EA mitigates cancer cachexia-induced fat loss by the activation of the RXRβ-PPARγ pathway.