TNF and skin disorder: Despite the ethnopharmacological applications of TLEO, the molecular basis of its dermatological efficacy remains poorly defined.<h4>Method</h4>This study integrated network pharmacology, molecular docking, and in vitro assays to systematically investigate how TLEO works against inflammatory skin conditions, focusing on its key compounds and biological targets.<h4>Results</h4>A total of 66 skin disorder-related genes were identified through network pharmacology, with gene enrichment analyses highlighting the TNF signaling pathway as a critical mediator.