PRDX5 and depressive symptom measurement: The ROS and NO levels in LPS-induced BV2 cells also significantly increased (p < 0.05).<h4>Conclusions</h4>This study revealed that Prdx1, Prdx2, Prdx4, and Prdx5 were elevated in depression models, which might relate to the occurrence of neuroinflammation, coupled with upregulation of oxidative stress responses.