The ROS and NO levels in LPS-induced BV2 cells also significantly increased (p < 0.05).<h4>Conclusions</h4>This study revealed that Prdx1, Prdx2, Prdx4, and Prdx5 were elevated in depression models, which might relate to the occurrence of neuroinflammation, coupled with upregulation of oxidative stress responses. Here, PRDX5 is linked to depressive disorder.