By contrast, in models of absence epilepsy, Ih is often altered in ventrobasal thalamic neurons, and local HCN blockade can reduce or abolish spike–wave discharges (SWD) and absence seizures, underscoring the model-dependent bidirectionality of HCN-mediated effects (65). This evidence concerns the gene MALAT1 and Generalized non-motor (absence) seizure.