In patients with Raynaud’s phenomenon, telangiectasia, puffy fingers, or skin thickening of the fingers, it is necessary to complete the search for the diagnosis of SSc (83, 84) with an immunoassay for other SSc-related autoantibodies (anti-CENP-A/B, anti–RNA polymerase III (RP 11 and 155), anti-fibrillarin, anti-Ku, anti-90-kd nucleolar protein (NOR-90), anti-Th/To, anti-PM/Scl-75, anti-PM/Scl-100, anti-Ro52/tripartite motif-containing protein 21 (TRIM21), and anti-platelet-derived growth factor receptor (PDGFR) antibodies) beyond ENA screening (anti-Scl-70 anti-CENP-B antibodies) (85). The gene discussed is TRIM21; the disease is telangiectasis.