The first-line screening tests for these autoimmune disorders include ANA and anti-extractable nuclear antigen antibodies (ENA) (anti-Ro/SSA, anti-La/SSB, anti-Sm, anti-RNP, anti-Jo1, anti-Scl-70 (anti-topoisomerase I), and anti-centromere (CENP-B) antibodies) (53, 54). The gene discussed is CALR; the disease is autoimmune disease.