globotriaosylsphingosine (lyso-Gb3 or -GL3) serum level for men or alpha-galactosidase A (GLA) gene mutation for women in the case of clinical symptoms (paroxysmal painful acroparesthesiae in familial or child-onset context, cardiomyopathic involvement, proteinuria, dyshidrosis, angiokeratoma) compatible with Fabry disease (107–109);. This evidence concerns the gene GLA and Fabry disease.