These nine genes span multiple ALS-relevant biological domains, including lipid metabolism (ABCA1, SLC25A20),19,28 mitochondrial function (LYRM5),29 RNA processing and stress signaling (DDX51, SRPK1, RPS6KA5),30,31,32 and immune regulation (QPCT).33 Here, ABCA1 is linked to amyotrophic lateral sclerosis.