These nine genes span multiple ALS-relevant biological domains, including lipid metabolism (ABCA1, SLC25A20),19,28 mitochondrial function (LYRM5),29 RNA processing and stress signaling (DDX51, SRPK1, RPS6KA5),30,31,32 and immune regulation (QPCT).33 Here, SLC25A20 is linked to amyotrophic lateral sclerosis.