SRPK1 and amyotrophic lateral sclerosis: These nine genes span multiple ALS-relevant biological domains, including lipid metabolism (ABCA1, SLC25A20),19,28 mitochondrial function (LYRM5),29 RNA processing and stress signaling (DDX51, SRPK1, RPS6KA5),30,31,32 and immune regulation (QPCT).33