When comparing ALS with other neurological disorders (OND), ABCA1 expression in the frontal cortex showed opposite directions across datasets (GSE153960: log2FC = 1.52, p = 1.5 × 10−12; GSE124439: log2FC = −0.54, p = 0.046). Here, ABCA1 is linked to amyotrophic lateral sclerosis.