IFNG and atopic eczema: Evidence based:•After 12 weeks IFN-γ significantly increased from 2.40 to 3.00 pg/mL (p < 0.02), while IL-10 decreased by 65.5% (p < 0.001).•Clinical trials:•After four weeks, symptoms associated with dyshidrotic dermatitis significantly reduced.•Post-SCORAD scores were reduced by a significance of p < 0.0002 when used on atopic dermatitis patients for a period of approximately seven weeks.