During spermatogenesis, they orchestrate non-redundant processes: IQCH regulates alternative RNA splicing of testis-specific transcripts to ensure spermatid maturation, while IQGAP1 maintains BTB integrity via actin cytoskeleton reorganization—both critical for preventing spermatogenic arrest and azoospermia. The gene discussed is IQGAP1; the disease is Azoospermia.