In cisplatin-induced AKI, NAD(P)H, quinone oxidoreductase 1 (NQO1)-deficient mice exhibited more severe renal injury, accompanied by increased expression of autophagy-related proteins but impaired autophagosome maturation (as evidenced by reduced Ras-associated protein 7 expression and p62 protein accumulation), suggesting that NQO1 may regulate autophagy through the AMPK/TSC2/mTOR signaling pathway to influence cisplatin-induced nephrotoxicity (Kim et al., 2016). Here, NQO1 is linked to acute kidney injury.