In a rat model of lipopolysaccharide (LPS)-induced AKI, both HIF-1α and aquaporin-1 (AQP1) were significantly upregulated within 12 h, concomitant with hypoglycemia, enhanced glycolysis, and a pro-inflammatory shift (elevated IL-6/TNF-α and reduced IL-10). The gene discussed is AQP1; the disease is acute kidney injury.