In an ischemia-reperfusion-induced AKI mouse model, the expression of HIF-1α and BNIP3 increased, and autophagy and endoplasmic reticulum autophagy (ER-phagy) were activated (Zhao et al., 2025; Fu et al., 2020; Li J. et al., 2023). The gene discussed is BNIP3; the disease is acute kidney injury.