Renal ischemia-reperfusion injury can trigger acute liver injury and systemic inflammatory responses, with significant increases in mRNA and protein levels of pro-inflammatory cytokines (MCP-1, TNF-α, IL-6) in renal tissue and the liver, alongside activation of nuclear factor κB in the liver (Shang et al., 2020), suggesting that the systemic inflammatory response during AKI may indirectly involve the HIF-1α regulatory network. This evidence concerns the gene TNF and acute kidney injury.