Multiple studies show that FSTL1 is induced after ischemia–reperfusion or myocardial infarction, and giving exogenous FSTL1 in animal I/R models can reduce infarct size and lessen injury—suggesting it may be protective early in the acute damage phase (Ogura et al., 2012). The gene discussed is FSTL1; the disease is myocardial infarction.