This was demonstrated in the context of insulin resistance in diabetes, where the O-GlcNAc transferase (OGT) and host cell factor-1 (HCF-1) interact with PGC-1α to promote its O-GlcNAcylation, facilitating BAP1 recruitment for deubiquitination and protecting PGC-1α from degradation. The gene discussed is HCFC1; the disease is Insulin resistance.