Aside from VHL, the most frequently mutated genes in ccRCC are polybromo 1 (PBRM1), SET domain containing 2 (SETD2), and BRCA1-associated protein-1 (BAP1), all of which are chromatin modulators found on the short arm of chromosome 3p (Dalgliesh et al., 2010; Peña-Llopis et al., 2012; Varela et al., 2011). The gene discussed is SETD2; the disease is nonpapillary renal cell carcinoma.