Loss of heterozygosity on chromosome 3p, along with inactivation of the last copy of the tumor suppressor gene von Hippel-Lindau (VHL), located on chromosome 3p25-26, are key features of ccRCC (Kovacs et al., 1988; Kovacs et al., 1987; Latif et al., 1993). Here, VHL is linked to nonpapillary renal cell carcinoma.