NOTCH1 and neoplasm: This lack of subtype-specific mechanistic insights may lead to inconsistent efficacy-for example, resveratrol inhibits Notch1 (a key pro-tumor factor in breast cancer) to suppress breast cancer growth (Pandey et al., 2024; Dong et al., 2020; Lu and Serrero, 1999), underscoring the need for subtype-specific research.