Sulforaphane also inhibits Notch signaling and the expression of colorectal cancer stem cell markers, and ZNF217 overexpression can reverse this inhibition, indicating that sulforaphane targets the ZNF217/Notch1 axis to modulate Notch signaling and inhibit the stem-like properties of colorectal cancer cells (Wang M. et al., 2024). This evidence concerns the gene NOTCH1 and colorectal cancer.