In colon CSCs, quercetin combined with radiotherapy can reduce the levels of Jagged1 protein, γ-secretase complex components, and cleaved Notch1, upregulate miR-200b-3p, inhibit Notch signaling, change the division pattern of CSCs, and impair tumor regeneration (Kaveh Zenjanab et al., 2024). The gene discussed is NOTCH1; the disease is neoplasm.