Supporting this interpretation, our RNA-seq analysis revealed that the hypertrophy-inhibitory marker Rcan1 was significantly upregulated following HIIT in MI hearts, whereas classical pathological hypertrophy markers (Nppa, Nppb, and Nppc) tended to be lower, although these differences did not reach statistical significance (Supplementary Figure S4). The gene discussed is RCAN1; the disease is myocardial infarction.