Fusobacterium nucleatum activates the TLR4/AKT signaling pathway, downregulates Keap1, and upregulates NRF2, thereby enhancing the transcription of CYP2J2 and increasing the production of its metabolite, 12,13-EpOME, which in turn promotes EMT and metastasis in colorectal cancer. The gene discussed is AKT1; the disease is colorectal cancer.