CRLF3 is an evolutionarily conserved member of the class I cytokine receptor family which has been implicated in diverse biological processes including thrombopoiesis, immune regulation, neuronal development and neuroprotection, and has been associated with a variety of diseases including neurofibromatosis type I, autism spectrum disorders and ALS (Yang et al., 2009; Cirulli et al., 2015; Wegscheid et al., 2021; Bennett et al., 2022; Knorr et al., 2023; Wilson et al., 2023). This evidence concerns the gene CRLF3 and amyotrophic lateral sclerosis.