Carbohydrates are the main macronutrient of interest for dosing insulin and managing glycemia in type 1 diabetes (T1D) due to their direct impact on blood glucose levels, however, the influence of protein on glycemia and pancreatic islet hormone secretions in people living with either T1D or type 2 diabetes (T2D) should not be overlooked. This evidence concerns the gene INS and type 2 diabetes mellitus.