(27), which found that replacing a median of 35% of total protein per day with plant protein for a median duration of eight weeks significantly lowered HbA1c level (mean difference -0.15%, p=0.009), fasting glucose (mean difference -0.34 mmol/L, p=0.02), and fasting insulin level (mean difference -10.09 pmol/L, p=0.006) in individuals with T2D, suggesting that that plant protein substitution may help mitigate hyperglycemia and hyperinsulinemia in this population. This evidence concerns the gene INS and Hyperglycemia.