Compared with healthy controls, mRNA levels of EOMES, GZMA, IL2RB, and IL2RG were significantly upregulated in alopecia areata (AA) lesional scalp (all p<0.01), whereas androgenetic alopecia (AGA) scalp showed no significant increase relative to controls (all p>0.05). The gene discussed is IL2RB; the disease is alopecia areata.