Additionally, hsa_circ_0110,102 sponges miR-580-5p to downregulate PPARα and inhibit CCL2 secretion, subsequently suppressing the release of pro-inflammatory cytokines from macrophages via the COX-2/PGE2 pathway, exerting a tumor-suppressive effect (Wang et al., 2021b). The gene discussed is PPARA; the disease is neoplasm.