This is a significant concernin cancer therapy because through PD1-PDL1 interaction the tumor canlimit the effectiveness of the immune system in recognizing and destroyingcancer cells and contribute to shape an immune suppressive microenvironment.−, ,  We reasoned that using HFn-Dox may help preserve T cell functionby reducing aspecific distribution of the drug in the immune cellsand possibly avoiding T cells exhaustion. This evidence concerns the gene CD274 and cancer.