Dox formulation exploiting H-Ferritin (HFn) nanocages has beendeveloped and optimized over the years by our group showing to bean optimal candidate for clinical translation in TNBC therapy.−, ,  HFn are natural spheric nanoparticles with a uniform-size cavitythat can accommodate different kinds of drugs., They are internalized in the cells upon specific binding with theTransferrin receptor 1 (TfR1), overexpressed in almost all types ofhuman cancer, thus, ensuring natural homing to solid tumors. Here, TFRC is linked to cancer.