KEGG pathway enrichment analysis of high-MTSR samples and cluster 8 (Fig. 7E and F) consistently demonstrated enrichment in tumor-progression- and epithelial–mesenchymal transition (EMT)-related pathways, including the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathway, ECM–receptor interaction, Rap1 signaling, and WNT signaling. This evidence concerns the gene AKT1 and neoplasm.