Hyperglycemia also disrupts epigenetic regulation: overproduction of histone demethylases (e.g., JMJD3) and high DNMT1 levels suppress M2 polarization, while interventions such as DNMT1 inhibitors or modulation of MLL1-mediated H3K4me3 can restore M2 macrophage function. Here, DNMT1 is linked to Hyperglycemia.