HIF1A and asthma: This mechanism has received partial support in asthma-related models: in OVA-induced allergic asthma mice and OVA-stimulated THP-1–derived macrophages, HIF-1α–driven enhancement of glycolysis, lactate accumulation, and protein lactylation are associated with increased pyroptosis of F4/80+ macrophages and aggravated airway pathology.